Large Conductance Calcium-Activated Potassium Channels Contribute to the Reduced Myogenic Tone of Peripheral Microvasculature After Cardiopulmonary Bypass
نویسندگان
چکیده
منابع مشابه
Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels
Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca(2+)-activated K(+) channels (BK(Ca) or Slo) are subject to redox regulation. However, conflicting results exist whether ...
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Rationale: Myogenic tone, an important regulator of vascular resistance, is dependent on vascular smooth muscle (VSM) depolarization, can be modulated by endothelial factors, and is increased in several models of hypertension. Intermittent hypoxia (IH) elevates blood pressure and causes endothelial dysfunction. Hydrogen sulfide (H 2 S), a recently described endothelium-derived vasodilator, is p...
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AIMS Small-conductance calcium-activated potassium (SK) channels are expressed in the heart of various species, including humans. The aim of the present study was to address whether SK channels play a functional role in human atria. METHODS AND RESULTS Quantitative real-time PCR analyses showed higher transcript levels of SK2 and SK3 than that of the SK1 subtype in human atrial tissue. SK2 an...
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Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeabil...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2009
ISSN: 0022-4804
DOI: 10.1016/j.jss.2009.03.043